Biological Microtechnology and BioMEMS Group :: Professor Joel Voldman


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Publications

 

2012

Przybyla, L. and J. Voldman (2012). "Probing embryonic stem cell autocrine and paracrine signaling using microfluidics." Annual Review of Analytical Chemistry, to appear.

Vahey, M. D. and J. Voldman (2012). Isodielectric separation and analysis of cells. Single-Cell Analysis: Methods and Protocols. S. Lindström and H. Andersson-Svahn, Springer Science+Business Media, to appear.

Przybyla, L. M. and J. Voldman (2012). "Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal." Proceedings of the National Academy of Sciences 109(3): 835-840. | PNAS | MIT News

Tsang, W. M., A. L. Stone, et al. (2012). "Insect-machine interface: A carbon nanotube-enhanced flexible neural probe." Journal of Neuroscience Methods 204(15): 355-65. | Download PDF

 

2011

Toh, Y.-C., K. Blagovic, et al. (2011). "Spatially organized in vitro models instruct asymmetric stem cell differentiation." Integrative Biology 3(12): 1179-1187. | Download PDF

Hoehl, M. M., S. K. Dougan, et al. (2011). MASSIVELY PARALLEL MICROFLUIDIC CELL-PAIRING PLATFORM FOR THE STATISTICAL STUDY OF IMMUNOLOGICAL CELL-CELL INTERACTIONS. Micro Total Analysis Systems. Seattle, WA USA: 1508-10.| Download PDF

Sun, T. and J. Voldman (2011). IMAGE-BASED SCREENING OF HIGH-PERFORMING CLONES USING PHOTOACTIVATED CELL SORTING VIA DUAL PHOTOPOYLMERIZED MICROWELL ARRAYS. Micro Total Analysis Systems. Seattle, WA USA: 693-5. | Download PDF

Toh, Y.-C., K. Blagovic, et al. (2011). DIFFERENTIAL ENVIRONMENTAL SPATIAL PATTERNING (δESP) RECREATES PROXIMAL-DISTAL AXIAL PATTERNS IN EMBRYONIC STEM CELL COLONIES. Micro Total Analysis Systems. Seattle, WA USA: 30-32. | Download PDF

 

Blagovic K, Kim LY, Voldman J (2011) Microfluidic Perfusion for Regulating Diffusible Signaling in Stem Cells. PLoS ONE 6(8): e22892. doi:10.1371/journal.pone.0022892 | Download PDF

M. D. Vahey and J. Voldman, "Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations," Lab on a Chip, vol. 11, pp. 2071-2080, 2011. | Download PDF

Y.-C. Toh and J. Voldman, "Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction," Faseb Journal, vol. 25, pp. 1208-17, 2011. | Download PDF

N. Mittal and J. Voldman, "Non-mitogenic survival-enhancing autocrine factors including cyclophilin a contribute to density-dependent mesc growth," Stem Cell Research, vol. 6, pp. 168-76, 2011.

S. P. Desai and J. Voldman, "Cell-based sensors for quantifying the physiological impact of microsystems," Integrative Biology, vol. 3, pp. 48-56, 2011. | Download PDF

 

2010

D. C. Daly, P. P. Mercier, M. Bhardwaj, A. L. Stone, Z. Aldworth, T. L. Daniel, J. Voldman, J. G. Hildebrand, and A. P. Chandrakasan, "A Pulsed UWB Receiver SoC for Insect Motion Control," IEEE Journal of Solid-State Circuits, vol. 45, pp. 153-66, 2010. | Download PDF

M. D. Vahey, J. P. Svensson, L. Quiros-Pesudo, L. D. Samson, and J. Voldman, "Genome-wide analysis of electrical phenotype using iso-dielectric separation," in Micro Total Analysis Systems, Groningen, Netherlands, pp. 725-7, 2010. | Download PDF

W. M. Tsang, A. L. Stone, Z. Aldworth, J. G. Hildebrand, T. Daniel, A. I. Akinwande, and J. Voldman, "Flexible split-ring electrode for insect flight biasing using multisite neural stimulation," IEEE Transactions on Biomedical Engineering, vol. 57, pp. 1757-64, 2010 Jul 2010. | Download PDF

W. M. Tsang, A. Stone, Z. Aldworth, D. Otten, T. Akinwande, T. Daniel, J. G. Hildebrand, R. Levine, and J. Voldman, "Remote control of a cyborg moth using carbon nanotube-enhanced flexible neuroprosthetic probe," in IEEE MEMS, Hong Kong, China, pp. 39-42, 2010. | Download PDF

Y.-C. Toh and J. Voldman, "Multiplex microfluidic perfusion identifies shear stress mechanosensing mediators in mouse embryonic stem cells," in Micro Total Analysis Systems, Groningen, Netherlands, pp. 10-12, 2010. | Download PDF

Y.-C. Toh, K. Blagovic, and J. Voldman, "Advancing stem cell research with microtechnologies: Opportunities and challenges," Integrative Biology, vol. 2, pp. 305-25, 2010. | Download PDF

N. Tandon, A. Marsano, R. Maidhof, K. Numata, C. Montouri-Sorrentino, C. Cannizzaro, J. Voldman, and G. Vunjak-Novakovic, "Surface-patterned electrode bioreactor for electrical stimulation," Lab on a Chip, vol. 10, pp. 692-700, 2010. | Download PDF

M. Carminati, M. D. Vahey, A. Rottigni, G. Ferrari, J. Voldman, and M. Sampietro, "Enhancement of a label-free dielectrophoretic cell sorter with an integrated impedance detection system," in Micro Total Analysis Systems, Groningen, Netherlands, pp. 1394-6, 2010. | Download PDF

 

2009

S. P. Desai, D. M. Freeman, and J. Voldman, "Plastic masters - rigid templates for soft lithography," in Micro Total Analysis Systems, Jeju, Korea, 2009, pp. 1025-7. | Downlaod PDF

K. Blagovic, S. P. Desai, and J. Voldman, "Micro-patterned polystyrene substrates for highly integrated microfluidic cell culture " in Micro Total Analysis Systems 2009, Jeju, Korea, 2009, pp. 144-6. | Download PDF

Y.-C. Toh and J. Voldman, "In vitro construction of complex stem cell microenvironments by stencil-and-flip cell patterning (saf-cp) " in Micro Total Analysis Systems, Jeju, Korea, 2009, pp. 1327-9. | Download PDF

Kovac, J. R., B. M. Taff, and J. Voldman, "Enabling Technologies for Image-Based Cell Sorting," in Microdevices in Biology and Medicine, Y. Nahmias and S. Bhatia, Eds. Boston: Artech House, 2009, pp. 129-48.

Voldman, J., "Going My Way?," Nature Physics, vol. 5, pp. 536-7, 2009. | Nature Physics

Voldman, J., "Interfacing Devices with Cells," Device Research Conference, State College, PA, 2009. | Download PDF

Cui, H.-H., J. Voldman, X.-F. He, and K.-M. Lim, "Separation of Particles by Pulsed Dielectrophoresis," Lab on a Chip, vol. 9, pp. 2306-2312, 2009. | Download PDF

Desai, S. P., D. M. Freeman, and J. Voldman, "Plastic Masters - Rigid Templates for Soft Lithography," Lab on a Chip, vol. 9, no. 11 pp. 1631-7, Jun 7 2009. | Download PDF

Vahey, M. D. and J. Voldman, "Characterization of Diverse Cell and Particle Types Using Iso-Dielectric Separation," Analytical Chemistry, vol. 81, no. 7 pp. 2446-55, 2009. | Download PDF

Taff, B. M., S. P. Desai, and J. Voldman, "Electroactive Hydrodynamic Weirs for Microparticle Manipulation and Patterning," Applied Physics Letters, vol. 94, no. 8 pp. 084102-3, 2009. | Download PDF

Desai, S. P., M. D. Vahey, and J. Voldman, "Vesicle Libraries - Tools for Dielectrophoresis Metrology," Langmuir, vol. 25, no. 6 pp. 3867-75, 2009. | Download PDF

Daly, D. C., P. P. Mercier, M. Bhardwaj, A. L. Stone, J. Voldman, R. Levine, J. G. Hildebrand, and A. P. Chandrakasan, "A Pulsed Uwb Receiver Soc for Insect Motion Control," ISSCC, San Francisco, 2009.

Skelley, A. M., Kirak, O., Suh, H., Jaenisch, R., & Voldman, J.,"Microfluidic Control of Cell Pairing and Fusion," Nature Methods 6, 147-52, 2009. | Nature Methods | MIT News | NY Times

2008

Blagovic, K., Kim, L. Y., Skelley, A. M., & Voldman, J., "Microfluidic control of stem cell diffusible signaling," Micro Total Analysis Systems '08 677-679, 2008. | Downoad PDF

Cui, H.-H., Lim, K.-M., & Voldman, J., "Experiment and modeling of pillar array micro-traps with negative dielectrophoresis," Micro Total Analysis Sytems '08 1012-14, 2008. | Download PDF

Desai, S. P. & Voldman, J., "Measuring the impact of dielectrophoresis on cell physiology using a high-content screening platform," Micro Total Analysis Systems '08 1308-10, 2008. | Download PDF

Sampattavanich, S., Taff, B. M., Desai, S. P., & Voldman, J., "Organizing complex multicellular constructs using stencil-delineated electroactive patterning (S-DEP)," Micro Total Analysis Systems '08 567-69, 2008. | Download PDF

Skelley, A. M. & Voldman, J., "An active, integrated bubble trap and debubbler for microfluidic applications," Micro Total Analysis Systems '08 1360-62, 2008. | Download PDF

Tsang, W. M., Aldworth, Z., Stone, A., Permar, A., Levine, R., Hildebrand, J. G., Daniel, T., Akinwande, A. I., & Voldman, J., "Insect flight control by neural stimulation of pupae-implanted flexible multisite electrodes," Micro Total Analysis Systems '08 1922-24, 2008. | Download PDF

Vahey, M. D. & Voldman, J., "High-throughput cell and particle characterization using iso-dielectric separation," Micro Total Analysis Systems '08 1187-89, 2008. | Download PDF

Vahey, M. D. & Voldman, J., "Sorting concentrated suspensions: particle interactions, emergent behavior, and implications for microfluidic separations," Micro Total Analysis Systems '08 1474-76, 2008. | Download PDF

Skelley, A. M. & Voldman, J., "An Active Bubble Trap and Debubbler for Microfluidic Systems," Lab Chip 8 (10), 1733-7, 2008. | Download PDF

Tandon, N., Marsano, A., Cannizzaro, C., Voldman, J., & Vunjak-Novakovic, G., "Design of electrical stimulation bioreactors for cardiac tissue engineering," 30th Annual International Conference of the IEEE-EMBS 2008.

Desai, S. P., Taff, B. M., & Voldman, J., "A photopatternable silicone for biological microsystems " Langmuir 24 575-81, 2008. | Download PDF

Kovac, J. R. & Voldman, J., "Image-based cell sorting using optofluidics," 2008 IEEE/LEOS Summer Topical Meeting on Optofluidics July 21-23, 2008 2008.

Robinson, T. D., Ooi, B.-H., Taff, B. M., Willcox, K. E., & Voldman, J., "Surrogate-Based Optimization of a Microfluidic Weir Structure for Single-Cell Manipulation," 12th AIAA/ISSMO Multidisciplinary Analysis and Optimization Conference 2008.

Cui, H.-H., Lim, K.-M., Lim, S.-P., Khoo, B.-C., & Voldman, J., "Microparticle Separation using Dynamic Pulsed Dielectrophoresis,"Microscale BioSeparations 2008 2008.

Daly, D. C., Bhardwaj, M., Lee, F. S., Mercier, P. P., Wentzloff, D. D., Voldman, J., & Chandrakasan, A. P., "Energy Efficient Pulsed-UWB Transceiver for Insect Flight Control," GOMACTech 2008.

Vahey, M. D. & Voldman, J., "A new equilibrium method for continuous-flowcell sorting using dielectrophoresis," Analytical Chemistry 80 (9), 3135-43, 2008. | Download PDF

2007

Mittal, N., S. Flavin and J. Voldman. "Patterning of embryonic stem cells using the bio flip chip." Journal of Visualized Experiments, Issue 8 (2007). | Video

Kovac, J. R. and J. Voldman. "Intuitive, Image-Based Cell Sorting Using Opto-fluidic Cell Sorting." Analytical Chemistry 79(24): 9321-30, (2007). | Download PDF | Download Supporting Information | Dowload Video | Download Video 2 | MIT News Office Story | Analytical Chemistry Feature Story

Desai, S. P., B. M. Taff, et al. A photopatternable silicone for BioMEMS applications. Micro Total Analysis Systems '07, 448-50 (2007). | Download  PDF

Desai, S. P., M. D. Vahey, et al. Vesicle libraries - tools for dielectrophoresis metrology. Micro Total Analysis Systems '07, 1104-6 (2007). | Download PDF

Skelley, A. M., O. Kirak, et al. Studying reprogramming of somatic cells via fusion with embryonic s tem cells: a massively parallel device for cell fusion. Micro Total Analysis Systems '07, 581-3 (2007). | Download PDF

Taff, B. M., S. P. Desai, et al. Dielectrophoretically switchable microfluidic weir structures for exclusion-based single-cell manipulation. Micro Total Analysis Systems '07, 8-10 (2007). | Download PDF

Vahey, M. D., R. J. Barsotti, et al. Modeling the electrokinetics of nanoparticles for controlled assembly. Micro Total Analysis Systems '07, 991-3 (2007). | Download PDF

Kim, E., M. J. Mescher, et al. Microfluidic continuous bacteria concentrator with integrated microvalves. MicroScale Bioseparations 2007 (2007).

Kim, L., Y. C. Toh, et al. "A practical guide to microfluidic perfusion culture of adherent mammalian cells." Lab Chip 7(6): 681-94 (2007). | Download PDF

Lee, H.-Y. and J. Voldman. "Optimizing Micromixer Design for Enhancing Dielectrophoretic Microconcentrator Performance." Analytical Chemistry 79(5): 1833-9 (2007). | Download PDF | Download Supporting Information

Mittal, N., A. Rosenthal, et al. "nDEP Microwells for Single-Cell Patterning in Physiological Media." Lab Chip 7(9): 1146-53 (2007). | Download PDF | Download Video

Rosenthal, A., A. Macdonald, et al. "Cell patterning chip for controlling the stem cell microenvironment." Biomaterials 28(21): 3208-16 (2007). | Download PDF

Barsotti, R. J., M. D. Vahey, R. Wartena, Y.-M. Chiang, J. Voldman and F. Stellacci. "Assembly of metal nanoparticles into nanogaps." Small 3(3): 488-99 (2007). | Download PDF (900kB) | Download Supplemental Information

2006

Voldman, J. (2006). Dielectrophoretic Traps for Cell Manipulation. BioMEMS and Biomedical Nanotechnology. R. Bashir, S. Wereley and M. Ferrari, Kluwer. 4: 159-86. | Download PDF


Gadish, N. & Voldman, J. High-Throughput Positive-Dielectrophoretic Bioparticle Microconcentrator. Analytical Chemistry 78 (2006), 7870-7876. | Download PDF

Kovac, J.R. & Voldman, J. Facile Image-based Cell Sorting Using OPTO-FluCS (Opto-fluidic cell sorting). in Micro Total Analysis Systems '06 2, 1483-1485 (2006). | Download PDF

Vahey, M.D. & Voldman, J. Iso-dielectric Separation: A new method for the continuous-flow screening of cells. in Micro Total Analysis Systems '06 2, 1058-1060 (2006). | Download PDF

Voldman, J. Electrical forces for microscale cell manipulation. Annu. Rev. Biomed. Engr. 8 (2006), 425- 454. | Download PDF

Voldman, J. Engineered systems for the physical manipulation of single cells. Current Opinion in Biotechnology 17 (2006), 532-537. | Download PDF

Rosenthal, A., Taff, B. M., & Voldman, J. Quantitative modeling of dielectrophoretic traps. Lab on a Chip 6 (2006), 508-515. | Download supplementary info | Download software | Download PDF

Kim, L.Y., Vahey, M.D., Lee, H.-Y. & Voldman, J. Microfluidic arrays for logarithmically perfused embryonic stem cell culture. Lab on a Chip 6 (2006), 394-406. | Download PDF

2005

Taff, B.M. & Voldman, J. A Scalable Addressable Positive-Dielectrophoretic Cell-Sorting Array. Analytical Chemistry 77, 7976-7983 (2005). | Download PDF

Taff, B.M. & Voldman, J. in Micro Total Analysis Systems '05, Vol. 2. (eds. J. Han, D. Harrison, K.F. Jensen & J. Voldman) 865-867 (Transducers Research Foundation, Boston, MA, USA; 2005). | Download PDF

Kim, L.Y., Lee, H.-Y. & Voldman, J. in Micro Total Analysis Systems '05, Vol. 1. (eds. J. Han, D. Harrison, K.F. Jensen & J. Voldman) 530-532 (Transducers Research Foundation, Boston, MA, USA; 2005). | Download PDF

Rosenthal, A., and Voldman, J. Dielectrophoretic traps for single-particle patterning. Biophys. J. 88: 2193-2205 (2005). | Download PDF

2004

Gray, D.S., Tan, J.L., Voldman, J. & Chen, C.S. Dielectrophoretic registration of living cells to a microelectrode array. Biosensors and Bioelectronics 19, 1765-1774 (2004). | Download PDF

Rosenthal, A., and Voldman, J. Simple, strong, and size-selective dielectrophoretic trap for single-cell patterning. Micro Total Analysis Systems '04, Malmo, Sweden, 228-230 (2004). | Download PDF

2003

Voldman, J. BioMEMS - Building with cells. Nature Materials 2, 433-434 (2003). | Download PDF

Voldman, J., Toner, M., Gray, M.L. & Schmidt, M.A. Design and analysis of extruded quadrupolar dielectrophoretic traps. Journal of Electrostatics, 57, 69-90 (2003). | Download PDF

2002

Voldman, J., Toner, M., Gray, M.L. & Schmidt, M.A. A Microfabrication-Based Dynamic Array Cytometer. Analytical Chemistry 74, 3984-3990 (2002). | Download PDF

2001

Voldman, J., Toner, M., Gray, M.L. & Schmidt, M.A. A dielectrophoresis-based array cytometer. Transducers '01, 322-325 (2001). | Download PDF

Voldman, J., Braff, R.A., Toner, M., Gray, M.L. & Schmidt, M.A. Holding Forces of Single-Particle Dielectrophoretic Traps. Biophys. J. 80, 531-541 (2001). | Download PDF

Voldman, J. A Microfabricated dielectrophoretic trapping array for cell-based biological assays. Ph.D. Thesis, MIT, 2001. | Download PDF

2000

Voldman, J., Gray, M.L. & Schmidt, M.A. An integrated liquid mixer/valve. Journal of Microelectromechanical Systems 9, 295-302 (2000). | Download PDF

Voldman, J., Braff, R.A., Toner, M., Gray, M.L. & Schmidt, M.A. Quantitative design and analysis of single-particle dielectrophoretic traps. Micro Total Analysis Syst. '00. (eds. A. van den Berg, W. Olthius & P. Bergveld) 431-434 (2000). | Download PDF

1999

Voldman, J., Gray, M.L. & Schmidt, M.A. Microfabrication in Biology and Medicine. Annu. Rev. Biomed. Engr. 1, 401-425 (1999). | Download PDF

1998

Voldman, J., Gray, M.L. & Schmidt, M.A. Liquid mixing studies using an integrated mixer/valve. Micro Total Analysis Syst. '98. (eds. D. Harrison & A. van den Berg) 181-184 (1998). | Download PDF

 

 

 

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