Integrative Neuromonitoring and
Critical Care Informatics Group

Professor Thomas Heldt

Publications

Selected publications

  1. Birjiniuk J, Heldt T. Tracking autonomic balance using an open-loop model of the arterial baroreflex. American Journal of Physiology. (In press.)
  2. Diaz-Artiles A, Heldt T, Young LR. Short-term cardiovascular response to short-radius centrifugation with and without ergometer exercise. Frontiers in Physiology 9:1492, 2018.
  3. Filbin MR, Lynch JC, Gillingham TD, Thorsen JE, Pasakarnis C, Nepal S, Matsushima M, Rhee C, Heldt T, Reisner AT. Presenting symptoms independently predict mortality in septic shock: Importance of a previously unmeasured confounder. Critical Care Medicine 46 (10), 1592-1599, 2018.
  4. Filbin MR, Thorsen JE, Lynch JC, Gillingham TD, Pasakarnis C, Capp R, Shapiro NI, Mooncai T, Hou PC, Heldt T, Reisner AT. Challenges and opportunities for emergency department sepsis screening at triage. Scientific Reports 8(1): 11059, 2018.
  5. Lai H-Y, Saavedra-Peña G, Sodini CG, Heldt T, Sze V. Enabling saccade latency measurements with consumer-grade cameras. Proceedings of the 25th IEEE International Conference on Image Processing, pp. 3169-3173, 2018.
  6. Saavedra-Peña G, Lai H-Y, Sze V, Heldt T. Determination of saccade latency distributions using video recordings from consumer-grade devices. Proceedings of the 4oth IEEE Engineering in Medicine and Biology Conference, 2018.
  7. Birjiniuk J, Gordhandas A, Verghese GC, Heldt T. A fiducial scaffold for ECG compression in low-power devices. Proceedings of the 4oth IEEE Engineering in Medicine and Biology Conference, 2018.
  8. Shim EB, Heldt T. Fluid-structure interaction in the cerebral venous transverse sinus. Proceedings of the 4oth IEEE Engineering in Medicine and Biology Conference, 2018.
  9. Karasan E, Abid A, Mieloszyk RJ, Krauss BS, Heldt T, Verghese GC. An enhanced mechanistic model for capnography, with application to CHF-COPD discrimination. Proceedings of the 4oth IEEE Engineering in Medicine and Biology Conference, 2018.
  10. Li T, Matsushima M, Timpson W, Young S, Miedema D, Gupta M, Heldt T. Epidemiology of bedside monitoring alarms in the neonatal intensive care unit. Journal of Perinatology 38:1030-1038, 2018.
  11. Jinadasa SP, Mueller A, Prasad V, Subramaniam K, Heldt T, Novak V, Subramaniam B. Blood pressure coefficient of variation before, during, and after cardiopulmonary bypass and its association with cardiac surgical outcomes. Anesthesia & Analgesia, 127 (4) 832-839, 2018.
  12. Matthew JM, Fanelli A, Heldt T. An embedded device for real-time noninvasive intracranial pressure estimation. Acta Neurochirurgica Scandinavica Supplement 126:85-88, 2018.
  13. Fanelli A, Jainshankar R, Fillipidis A, Holsapple J, Heldt T. A waveform archiving system for the GE Solar 8000i bedside monitor. Acta Neurochirurgica Scandinavica Supplement 126:173-178, 2018.
  14. Prasad V, Guerrisi M, Dauri M, Coniglione F, Tisone G, De Carolis E, Cillis A, Canichella A, Toschi N, Heldt T. Prediction of post-operative outcomes using intraoperative hemodynamic monitoring data. Scientific Reports 7(1):16376, 2017.
  15. Abid A, Mieloszyk R, Verghese GC, Krauss B, Heldt T. Model-based estimation of respiratory parameters from capnography, with application to diagnosing obstructive lung disease.  IEEE Transactions on Biomedical Engineering 64(12):2957-2967, 2017.
  16. Prasad V, Lynch JC, Pasakarnis CL, Thorsen JE, Filbin MR, Reisner AT, Heldt T. “Classification models to predict vasopressors administration for septic shock in the emergency department,” Proceedings of the 39th Annual Conference of the IEEE Engineering in Medicine and Biology Society, pp. 2650-2653, 2017.
  17. Imaduddin SM, Heldt T. “Model-based estimation of radial artery blood pressure from recordings of the Nexfin monitor,” Proceedings of the 39th Annual Conference of the IEEE Engineering in Medicine and Biology Society, pp. 1692-1695, 2017.
  18. Dekimpe R, Heldt T. “Reducing false asystole alarms in critical care,” Proceedings of the 39th Annual Conference of the IEEE Engineering in Medicine and Biology Society, pp. 2292-2295, 2017.
  19. Fanelli A, Vonberg FW, Jaishankar R, Syed IM, Tasker RC, Heldt T. “Regression-based noninvasive estimation of intracranial pressure,” Proceedings of the 39th Annual Conference of the IEEE Engineering in Medicine and Biology Society, pp. 4001-4004, 2017.
  20. Mieloszyk RJ, Krauss BS, Montagu D, Andolfatto G, Barbi E, Verghese GC, Heldt T. “Statistical analysis of the age dependence of the normal capnogram,” Proceedings of the 39th Annual Conference of the IEEE Engineering in Medicine and Biology Society, pp. 345-348, 2017.
  21. Wadehn F, Walser D, Bohdanowicz M, Czosnyka M, Heldt T. “Noninvasive detection of intracranial hypertension using Random Forests,” Computing in Cardiology 44:323-326, 2017.
  22. Dias-Artiles A, Heldt T, Young L. Effects of artificial gravity on the cardiovascular system: Computational approach. Acta Astronautica 126: 395-410, 2016.
  23. Noraky J, Verghese GC, Searls DE, Lioutas V, Sonni S, Thomas A, Heldt T. Noninvasive intracranial pressure determination in patients with subarachnoid hemorrhage. Acta Neurochirurgica Scandinavica 122:65-68, 2016.
  24. Heldt T. Fluid dynamics of disease transmission. Science Translational Medicine 8 (328): 328ec36, 2016. (Editor’s Choice feature)
  25. Heldt T. Know the shunt flow. Science Translational Medicine 7 (316): 316ec208, 2015. (Editor’s Choice feature)
  26. Heldt T. Beep, beeep, beeeep, beeeeep. Science Translational Medicine 7 (310): 310ec181, 2015. (Editor’s Choice feature)
  27. Heldt T. The computational model will see you now. Science Translational Medicine 7 (304): 304ec154, 2015. (Editor’s Choice feature)
  28. Heldt T. Ultrasound made easy. Science Translational Medicine 7 (298): 298ec130, 2015. (Editor’s Choice feature)
  29. Heldt T. Measuring blood pressure with your bathroom scale. Science Translational Medicine 7 (292): 292ec101, 2015. (Editor’s Choice feature)
  30. Heldt T. Towards personalized medicine for the tiniest patients. Science Translational Medicine 7 (290): 290ec91, 2015. (Editor’s Choice feature)
  31. Mieloszyk RJ, Verghese GC, Deitch K, Cooney B, Khalid A, Mirre-González M, Heldt T, Krauss BS. Automated quantitative analysis of capnogram shape for COPD-Normal and COPD-CHF classification. IEEE Transactions on Biomedical Engineering 61(12):2882-2890, 2014. (Preprint, TBME Feature)
  32. Subramaniam B,  Khabbaz KR, Heldt T, Lerner AB, Mittleman MA, Davis RB, Goldberger AL, Costa MD. Blood pressure variability: Can nonlinear dynamics enhance risk assessment during cardiovascular surgery. Journal of Cardiothoracic and Vascular Anesthesia 28(2):392-397, 2014.
  33. Reisner AT, Heldt T. A computational model of hemorrhage and dehydration suggests a pathophysiological mechanism: Starling-mediated protein trapping. American Journal of Physiology, 304(4):H620-31, 2013.
  34. Ranger M, Johnston CC, Rennick JE, Limperopoulos C, Heldt T, du Plessis AJ. A multidimensional approach to pain assessment in critically ill infants during a painful procedure. Clinical Journal of Pain 29(7): 613-620, 2013.
  35. Heldt T, Verghese GC, Mark RG. Mathematical modeling of physiological systems. In “Mathematical modeling and validation in physiology: applications to the cardiovascular and respiratory systems,”  JJ Batzel, M Bachar, F Kappel (eds), Springer Verlag, 2013.
  36. Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T. Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial blood pressure. Science Translational Medicine 4 129ra44, 2012. (full-text, reprint)
  37. Heldt T, Kashif FM, Sulemanji M, O’Leary HM, du Plessis AJ, Verghese GC. Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings. Acta Neurochirurgica Supplementum 114: 177-180, 2012.
  38. Saeed M, Villaroel M, Reisner AT, Clifford G, Lehman LW, Moody G, Heldt T, Kyaw TG, Moody B, Mark RG. Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II): A public-access intensive care unit database. Critical Care Medicine 39(5): 952-960, 2011.
  39. Heldt T, Mukkamala R, Moody GB, Mark RG. CVSim: a cardiovascular simulator for teaching and research. The Open Pacing, Electrophysiology and Therapy Journal 3: 45-54, 2010.
  40. Sun JX, Reisner TA, Saeed M, Heldt T, and Mark RG. The cardiac output from blood pressure algorithms trial. Critical Care Medicine 37(1), 72-80, 2009.
  41. Parlikar TA, Heldt T, Verghese GC. Cycle-averaged models of cardiovascular dynamics. IEEE Trans. Circuits and Systems I: Fundamental Theory and Applications 53 (11): 2459 – 2468, 2006. (Special Issue on Advances in Life Sciences Systems and Applications)
  42. Heldt T. Continuous blood-pressure derived cardiac output monitoring – Should we be thinking long-term? Journal of Applied Physiology 101, 373-374, 2006. (Editorial)
  43. Heldt T, Chang JL, Chen JJS, Verghese GC, Mark RG. Cycle-averaged dynamics of a periodically-driven, closed-loop circulation model. Control Engineering Practice 13(9): 1163 – 1171, 2005. (Special Issue on Modelling and Control in Biomedical and Biological Systems)
  44. Heldt T, Shim EB, Kamm, RD, and Mark RG. Computational modeling of cardiovascular response to orthostatic stress. Journal of Applied Physiology 92, 1239-1254, 2002.

 

Selected conference publications and presentations

  1. Imaduddin SM, LaRovere KL, Kussman BD, Heldt T. Automated cerebral microembolus identification in pediatric patients using transcranial Doppler ultrasound. 2019 American Institute for Ultrasound in Medicine Convention, Orlando, Florida, 2019.
  2. LaRovere KL, Imaduddin SM, Heldt T, Kussman BD. Emboli monitoring in children undergoing cardiac catheterization or on mechanical circulatory support – Differentiating embolus from artifact is not so easy. American Institute for Ultrasound in Medicine Convention, Orlando, Florida, 2019.
  3. Timpson W, Lynch JC, Miedema D, Vinci C, Waldo K, Wasiak M, Young S, Heldt T, Gupta M. Responding to an alarming problem: Decreasing alarm burden and increasing safety in the NICU. Annual Meeting of the American Academy of Pediatrics, 2018.
  4. Prasad V, Lynch JC, Gillingham TD, Nepal S, Filbin MR, Reisner RT, Heldt T. Prediction of initiation of vasopressor administration in emergency department patients at risk of septic shock. Annual Conference of the American Medical Informatics Association, San Francisco, November 2018.
  5. Wadehn F, Mack DJ, Keller E, Heldt T. A multiscale intracranial pressure simulator. Annual Computing in Cardiology Conference, Maastricht, The Netherlands, September 2018.
  6. Ho T, Matsushima M, Gupta M, Heldt T, Timpson W. Clinical correlates of out-of- target oxygen saturation in the preterm neonate. Annual Meeting of the Pediatric Academic Societies, Toronto, CA, May 2018.
  7. Wahden F, Fanelli A, Heldt T. Binary classification of cerebral blood flow velocity waveforms. IEEE Engineering in Medicine and Biology Conference, Orlando, FL, August 2016.
  8. Fanelli A, Peterson J, Heldt T. Challenges in recording multi-parameter waveform signals in the neuro ICU. 16th International Conference on Intracranial Pressure & Neuromonitoring, Cambridge, MA, June 2016.
  9. Fanelli A, Filippidis A, Holsapple J, Heldt T. A waveform archiving system for the GE Solar 8000i bedside monitor. 16th International Conference on Intracranial Pressure & Neuromonitoring, Cambridge, MA, June 2016.
  10. Li T, Matsushima M, Timpson W, Young S, Gupta M, Heldt T. Epidemiology of bedside monitoring alarms in the neonatal critical care unit. Annual meeting of the Pediatric Academic Societies, Baltimore, MD, April 2016.
  11. Prasad V, Ha A,  Mujica F, Henriques T, Mueller A, Novack V, Khabbaz K, Heldt T, Subramaniam B. Measuring Intraoperative BP Variability via Poincare Plots to Assess Cardiac Surgical Outcomes. Society of Cardiovascular Anesthesiologists Annual Meeting 2016. San Diego, CA, April 2016.
  12. Ha A, Prasad V, Mujica F, Mueller A, Mathur P, Lerner AB, Khabbaz K, Novack V, Heldt T, Subramaniam B. Measuring Intraoperative Blood Pressure Variability with the Coefficient of Variation to Assess Cardiac Surgical Outcomes. Society of Cardiovascular Anesthesiologists Annual Meeting 2016. San Diego, CA, April 2016.
  13. Mujica F, Ha A, Prasad V, Mueller A, Mathur Pooja,  Lerner AB, Khabbaz K, Heldt T, Subramaniam B. Intraoperative Beat-by-Beat Blood Pressure vs. 15-Sec Sampling Variability: Does Resolution Matter? Society of Cardiovascular Anesthesiologists Annual Meeting 2016. San Diego, CA, April 2016.
  14. Dunitz M, Verghese GC, Heldt T. Predicting hyperlactatemia in the MIMIC II database. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Milan, Italy, 2015.
  15. Abid A, Mieloszyk R, Verghese GC, Krauss BS, Heldt T. Model-based estimation of pulmonary compliance and resistance parameters from time-based capnography. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Milan, Italy, 2015.
  16. Mieloszyk R, Guo M, Verghese GC, Andolfatto G, Heldt T, Krauss BS. Clustering capnogram features to track state transitions during procedural sedation. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Milan, Italy, 2015.
  17. Prasad V, Toschi N, Canichella A, Marcellucci M, Coniglione F, Dauri M, Guerrisi M, Heldt T. Intraoperative hemodynamics predict postoperative mortality in orthotopic liver transplantation. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Milan, Italy, 2015.
  18. Diaz A, Heldt T, Young LR. Cardiovascular Response to Artificial Gravity Combined with Exercise. 2015 IEEE Aerospace Conference, Big Sky, MT.
  19. Fanelli A, Heldt T. Signal quality quantification and waveform reconstruction of arterial blood pressure recordings. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Chicago, IL, USA.
  20. Noraky J, Verghese GC, Searls DE, Lioutas V, Sonni S, Thomas A, Heldt T. Noninvasive intracranial pressure determination in patients with subarachnoid hemorrhage. 15th International Conference on Intracranial Pressure and Brain Monitoring, Singapore, November 2013.
  21. Heldt T, Verghese GC. Modeling the morphology of the intracranial pressure waveform. 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Osaka, Japan, July 2013.
  22. Ranger M, Johnston CC, Rennick JE, Limperopoulos C, Heldt T, du Plessis AJ. Near-infrared spectroscopy (NIRS) to measure nociception following noxious stimulation in critically ill infants. 14th World Congress on Pain, Milan, Italy, 2012.
  23. Fanelli A, Signorini MG, Heldt T. Extraction of fetal heart rate from maternal surface ECG with provisions for multiple pregnancies. Proceedings of the 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 6165-6168, 2012.
  24. Hwang I, Kashif FM, Czosnyka M, Heldt T, Verghese GC. A frequency-domain approach to model-based noninvasive intracranial pressure estimation from arterial pressure and cerebral blood flow Velocity. 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, USA, 2012.
  25. Haslam B, Gordhandas A, Ricciardi C, Verghese GC, Heldt T. Distilling clinically interpretable information from data collected on next-generation wearable monitors. Proceedings of the 33rd Annual Conference of the IEEE Engineering in Medicine and Biology Society, 1729-1732, 2012.
  26. Haslam B, Gordhandas A, Ricciardi C, Heldt T, Verghese GC. Relating noninvasive cardiac output and total peripheral resistance estimates to physical activity in an ambulatory setting. Proceedings of the AAAI Spring Symposium on Computational Physiology, 27-31, 2011.
  27. Gordhandas A, Heldt T, Verghese GC. Real-time extraction and analysis of key morphological features in the electrocardiogram for data compression and clinical decision. Proceedings of the AAAI Spring Symposium on Computational Physiology, 15-18, 2011.
  28. Heldt T, Verghese GC. Model-based data integration for clinical environments. Proceedings of the 32nd Annual Conference of IEEE Engineering in Medicine and Biology Society, 5209-5212, 2010.
  29. He DD, Winokur ES, Heldt T, Sodini CG. The ear as a location for wearable vital signs monitoring. Proceedings of the 32nd Annual Conference of IEEE Engineering in Medicine and Biology Society, 6389-6392, 2010.
  30. Kashif FM, Heldt T, Verghese GC. Model-based estimation of intracranial pressure and cerebral autoregulation. Computers in Cardiology 35:369-372, 2008.
  31. Parlikar TA, Heldt T, Ranade GV, Verghese GC. Model-based estimation of cardiac output and total peripheral resistance. Computers in Cardiology 34:379-381, 2007.
  32. Heldt T, Chang JL, Verghese GC, Mark RG. Cycle-averaged models of cardiovascular dynamics. Proc. of the 5th IFAC Symposium on Modelling and Control in Biomedical and Biological Systems 387 – 392, 2003.

 

Patents

  1. Parlikar TA, Ranade GV, Heldt T, and Verghese GC. Model-based method for continuous determination of cardiac output and peripheral vascular resistance. U.S. Patent 8,282,564, 10/09/2012.
  2. Parlikar TA, Heldt T, Mukkamala R, and Verghese GC. Model-based method for continuous determination of cardiac ejection fraction and ventricular end-diastolic volume. U.S. Patent 8,235,910, 08/07/2012.
  3. Parlikar TA, Heldt T, Mark RG, and Verghese GC. System and method for prediction and detection of circulatory shock. U.S. Patent 8,262,579, 09/11/2012.
  4. Kashif FM, Heldt T, Verghese GC. Systems, devices, and methods for noninvasive or minimally-invasive estimation of intracranial pressure and cerebrovascular autoregulation. U.S. Patent 8,366,627, 02/05/2013.
  5. Kashif FM, Heldt T, Verghese GC. Systems, devices, and methods for noninvasive or minimally-invasive estimation of intracranial pressure and cerebrovascular autoregulation. U.S. Patent 8,821,402, 09/02/2014.
  6. Asher RJ, Heldt T, Krauss BS, Verghese GC. System and methods for quantitative capnogram analysis. PCT/US2014/021015, filed Mar 6, 2014.
  7. Heldt T, Filbin MR, Reisner AT, Dunitz M, Verghese GC. Systems and methods to predict serum lactate.” US provisional patent application filed 8/10/2015.
  8. Mieloszyk R, Guo M, Verghese GC, Heldt T, Krauss BS. Systems and methods for predicting adverse events and assessing level of sedation.” (U.S. patent application and PCT filed on 8/12/2016)
  9. Heldt T, Filbin MR, Reisner AT. System and methods for sepsis care task management. U.S. patent application and PCT application filed on 2/16/2016.
  10. Imaduddin SM, Fanelli A, Heldt T, System and methods for model-based estimation and tracking of intracranial pressure. Provisional patent application filed on 05/02/2018.