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Jianping Fu
Postdoctoral Associate
Department of Mechanical Engineering
jpfu@mit.edu
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Jianping Fu received the B.E. degree
from the department of Mechanical Engineering at the University
of Science and Technology of China (USTC) in 2000. He received
the M.S. degree from the Mechanical Engineering department
at the University of California, Los Angeles (UCLA) in 2002, majored
in micro-electromechanical systems (MEMS). He joined the
Ph.D. program in the Mechanical Engineering department at
MIT in 2002. His major is biological engineering with a minor
of micro/ nanomechanics and engineering. His research interests
include micro/ nanofluidics,
micro/ nanosystems for single biomolecule observation and manipulation, biomolecule separation, nanostructure-biomolecule
interactions, MEMS/NEMS.
Research Goals:
Direct analysis of biologically-relevant entities such as nucleic acids and proteins offers the potential to outperform conventional analysis techniques and diagnostic methods through enhancements in speed, accuracy, and sensitivity. Nanofluidic systems with critical dimensions comparable to the molecular scale open up new possibilities for direct observation, manipulation and analysis of biomolecules (single or ensemble), thus providing a novel basis for ultra-sensitive and high-resolution sensors and medical diagnostic systems. Inspired by this concept, we have developed a new class of nanofluidic filter devices and have implemented them as controllable molecular sieves for rapid analytical separation of various physiologically-relevant molecules such as proteins (see Research Project 1). In addition, we have conducted theoretical studies of molecular sieving process in the context of periodic free-energy landscapes created by the patterned nanofluidic filter arrays. The kinetic model constructed based upon the equilibrium partitioning theory and the Kramers rate theory properly describes the field-dependent sieving behavior, presenting notable progress beyond the existing equilibrium model in conventional gels (see Research Project 2). We have also invented a microfabricated anisotropic sieving structure consisting of a two-dimensional periodic nanofluidic filter array (anisotropic nanofilter array, ANA). The designed structural anisotropy in the ANA causes different-sized biomolecules to follow distinct migration trajectories, leading to efficient continuous-flow separation (see Research Project 3). Continuous-flow size-based separation of dsDNA and proteins covering broad biological size ranges were achieved within a few minutes, thus demonstrating the potential of the ANA as a generic molecular sieving structure for an integrated biomolecule sample preparation and analysis system (see Research Project 4).
Research Projects
1: Patterned one-dimensional periodic nanofilter arrays for rapid separation of DNA and proteins. (link)
2: Molecular sieving in periodic free-energy landscapes created by patterned nanofilter arrays. (link)
3: Deasign and fabrication of anisotropic two-dimensional nanofilter array (anisotropic nanofilter array: ANA) for continuous-flow separation of biomolecules. (link)
4: Continuous-flow Ogston sieving-based separation of short DNA and denatured proteins and entropic trapping-based separation of long DNA through the ANA. (link)
Cool device images and separation videos
REFERRED JOURNAL PUBLICATIONS AND BOOK CHAPTERS
1: Jongyoon Han, Jianping Fu, Ying-Chih Wang, and Yong-Ak Song, Encyclopedia of Microfluidics and Nanofluidics, Springer, in press, 2006.
2: Hansen Bow, Jianping Fu, Craig Rothman, and Jongyoon Han, submitted to Analytical Chemistry, Nov. 2006.
3: Jianping Fu, Reto B. Schoch, Anna L. Stevens, Steven R. Tannenbaum, and Jongyoon Han, Nature Nanotechnology,
vol. 2, 121-128, Feb. 2007. (pdf)
(Views by Robert Austin, “Nanofluidics: a fork in the nano-road," Nature Nanotechnology, vol. 2, 79-80, Feb. 2007) (pdf)
4: Jianping Fu, Juhwan Yoo, and Jongyoon Han, Physical Review Letter, vol. 97, 018103, July 2006. (selected for the July 15 2006 issue of Virtual Journal of Biological Physical Research and for the July 24 2006 issue of Virtual Journal of Nanoscale Science and Technology) (pdf‡)
Media exposure by MIT News Office, ScienceDaily, EurekAlert by AAAS, PhysOrg.com, etc.
5: Jianping Fu, Pan Mao, and Jongyoon Han, Applied Physics Letter, vol. 87, 263902, Dec. 2005. (selected for the Jan. 1 2006 issue of Virtual Journal of Biological Physical Research) (pdf†)
CONFERENCE PROCEDDINGS AND ABSTRACTS
1: Reto B. Schoch, Jianping Fu, Hansen Bow, and Jongyoon Han, MSB 2007: 20th International Symposium on Microscale Bioseparations, Vancouver, Canada, Jan. 2007.
2: Jianping Fu, and Jongyoon Han, Proc. 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (mTAS 2006), Tokyo, Japan, Nov. 2006, pp. 519-521. (pdf)
3: Jongyoon Han, Pan Mao, and Jianping Fu, 210th Joint International Meeting of the Electrochemical Society, Cancun, Mexico, Oct. 2006. (pdf)
4: Jianping Fu, and Jongyoon Han, American Physical Society National March Meeting, Baltimore, Maryland USA, March 2006. (pdf)
5: Jianping Fu, and Jongyoon Han, Proc. 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (mTAS 2005), Boston, Massachusetts USA, Oct. 2005, pp. 1531-1533. (pdf)
6: Jianping Fu, and Jongyoon Han, 2005 Gordon Research Conference on the Physics and Chemistry of Microfluidics, Oxford, UK, Aug. 2005.
7: Ying-Chih Wang, Jianping Fu, Pan Mao, and Jongyoon Han, Proc. 13th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers ’05), Seoul, Korea, June 2005, pp. 352-355. (pdf)
8: Jianping Fu, and Jongyoon Han, 18th International Symposium on MicroScale Bioseparation (MSB), New Orleans, Louisiana USA, Feb. 2005.
9: Jongyoon Han, and Jianping Fu, American Institute of Chemical Engineering (AIChE) National Meeting.Austin, Texas USA, Nov. 2004. 10: Jianping Fu, and Jongyoon Han, Proc. 26th IEEE-EMBS conference, San Francisco, California USA, Sept. 2004, pp. 2611-2614.
11: Jianping Fu, and Jongyoon Han, Proc. 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (mTAS 2004), Malmo, Sweden, Sept. 2004, pp. 285-287.
12: Jianping Fu, Ronggui Yang, Gang Chen, Jean Pierre Fleurial, and Jeffrey G. Snyder, Proc. 6th ASME-JSME Thermal Engineering Joint Conference, Hawaii Island, Hawaii USA, March 2003, pp. 332-337.
† Copyright by American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.
‡ Copyright by the American Physical Society.
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