Micro / Nanofluidic BioMEMS Group, Professor Jongyoon Han
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Publications
 

Papers in Refereed journals

2009

  1. Fu J., Mao P., Han J., "Continuous-flow bioseparation using microfabricated anisotropic nanofluidic sieving structures," Nature Protocols 4, - 1681 - 1698 (2009) (doi)
  2. Yamada M., Mao P., Fu J., Han J., "Rapid Quantification of Disease-Marker Proteins Using Continuous-Flow Immunoseparation in a Nanosieve Fluidic Device," Anal. Chem. 2009, 81, 7067–7074 (doi) (reprint)
  3. Lee, J.H., Cosgrove B., Lauffenburger A.D., Han J., “Microfluidic concentration-enhanced cellular kinase activity assay,” J. Am. Chem. Soc., 2009, 131, 10340–10341 (doi) (reprint)(reprint)
  4. Kim S.J., Li L., Han J., " Amplified Electrokinetic Response by Concentration Polarization near Nanofluidic Channel," Langmuir 2009, 25(13), 7759–7765 (doi) (reprint)
  5. Mao P. and Han J., "Massively-Parallel Ultra-High-Aspect-Ratio Nanochannels as Mesoporous Membranes," Lab on a Chip 2009, 9, 586–591 (doi)
  6. Wang R, Wang J.S., Liu G.R., Han J., Chen Y.Z.,  "Simulation of DNA Electrophoresis in Systems of Large Number of Solvent Particles by Coarse-Grained Hybrid Molecular Dynamics Approach," Journal of Computational Chemistry, 30 (4): 505-513 March 2009 (doi)
  7. Z.R., Liu G.R., Han J., Chen Y.Z., Wang J.H., Hadjiconstantinou N.G., “Transport of biomolecules in asymmetric nanofilter arrays,” Analytical and Bioanalytical Chemistry, 394, 427-435, 2009. (doi)

2008

  1. Duong-Hong D., Han J., Wang J.S., Hadjiconstantinou N.G., Chen Y.Z., Liu G.R., “Realistic Simulations of Combined DNA Electrophoretic and Electroosmotic Flows in Nano-Fluidic Devices,” Electrophoresis, 29, 4880-4886, 2008. (doi)
  2. Bow H., Fu J., Han J., "Decreasing effective nanofilter size by modulating electrical double layers: Separation enhancement in microfabricated nanofilters," Electrophoresis, 29, 1-6, 2008. (doi)
  3. Fu J., Mao P., and Han J., "Artificial molecular sieves and filters: a new paradigm for biomolecule separatio," Trends in Biotechnology 2008, 26 (6), 311-320 (pubmed)
  4. Schoch, R. B., Han, J., Renaud, P. "Transport phenomena in nanofluidics," Reviews of Modern Physics 80, 839-883, 2008 (pdf)
  5. Song, Y.-A., Batista, C., Sarpeshkar, R., Han, J., "Rapid fabrication of microfluidic polymer electrolyte membrane fuel cell in PDMS by surface patterning of perfluorinated ion-exchange resin", Journal of Power Sources 2008, 183, 674–677(doi)
  6. Sung Jae Kim, Jongyoon Han, "Self-Sealed Vertical Polymeric Nanoporous-Junctions for
    High-Throughput Nanofluidic Applications," Analytical Chemistry 2008, 80, 3507-3511. (doi)
  7. Zi Rui Li, Z.R., Gui Rong Liu, Yu Zong Chen, Jian-Sheng Wang, Hansen Bow, Yuan Cheng, Jongyoon Han, “Continuum Transport Model of Ogston Sieving in Patterned Nanofilter Arrays for Rod-like Biomolecule Separation, ” Electrophoresis 2008, 29, 329–339. (doi)
  8. Lee, J. H.; Song, Y.-A; Tannenbaum, S., Han, J. "Increase of Reaction Rate and Sensitivity of Low-Abundance Enzyme Assay using Micro/Nanofluidic Preconcentration Chip," Analytical Chemistry 2008, 80, 3198-3204 (doi)
  9. Chung S., Lee J. H., Moon M-W., Han J, Kamm R. D. "Non-lithographic wrinkle nanochannels for protein preconcentration," Adv. Mater. 2008, 20, 3011–3016. (doi)
  10. Lee J. H*.; Song Y.-A.*; Han J. "Multiplexed Proteomic Sample Preconcentration Device Using Surface-Patterned Ion-Selective Membrane," Lab Chip, 2008, 8, 596–601, (doi). * These authors contributed equally to this work.
  11. Han J., Fu J., and Schoch R.B., “Molecular Sieving Using Nanofilters: Past, Present and Future,” Lab Chip, 2008, 8, 23–33. (doi)
  12. Wang YC, and Han J, "Pre-binding dynamic range and sensitivity enhancement for immuno-sensors using nanofluidic preconcentrator," Lab Chip, 2008, 8, 392–394, (doi)

 

2007

  1. Schoch, R.B., Cheow, L.F., and Han, J., “Electrical Detection of Fast Reaction Kinetics in Nanochannels with an Induced Flow,” Nano Letters, ASAP Web Release Date: 2007-11-13; (Letter) (doi) (reprint)
  2. Lee, J. H., Chung, S., Kim, S. J. & Han, J. "Novel PDMS based protein preconcentration using a nanogap generated by junction gap breakdown,” Analytical Chemistry, 79, 6868 -6873, 2007. (doi)
  3. Kim, S. J.*, Wang, Y.-C.*, Lee, J. H., Jang, H. & Han, J. "Concentration polarization and nonlinear electrokinetic flow near a nanofluidic channel,” Physical Review Letters, 99, 044501.1-4 (2007). (pdf‡)
  4. Duong-Hong, D., Wang, J.-S., Liu, G. R., Chen, Y. Z., Han, J., Hadjiconstantinou, N. G. " Dissipative particle dynamics simulations of electroosmotic flow in nano-fluidic devices," Microfluid Nanofluid (2008) 4:219–225. (doi)
  5. Fu, J.*, Schoch, R. B.*, Stevens, A. L., Tannenbaum, S. R. & Han, J. "A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins,” Nature Nanotechnology 2, 121-128 (2007). (pdf) Comment: Austin, R. "Nanofluidics: a fork in the nano-road," Nature Nanotechnology 2, 79-80 (2007). (pdf)

2006

  1. Kim, S. J., Song, Y.-A., Skipper, P. L. & Han, J. "Electrohydrodynamic generation and delivery of monodisperse pico-liter droplets using the PDMS microchip," Analytical Chemistry 78, 8011-8019 (2006). (doi)
  2. Balducci, A., Mao, P., Han, J. & Doyle, P. S."Double-stranded DNA diffusion in slitlike nanochannels," Macromolecules 39, 6273-6281 (2006). (doi)
  3. Fu, J., Yoo, J. & Han, J. "Molecular sieving in periodic free-energy landscapes created by patterned nanofilter arrays," Physical Review Letters 97, 018103.1-4 (2006). (pdf‡)
  4. Song, Y.-A., Hsu, S., Stevens, A. & Han, J. "Continuous-flow pI-based sorting of proteins and peptides in a microfluidic chip using diffusion potential," Analytical Chemistry 78, 3528-3536 (2006). (doi)

2005

  1. Fu, J., Mao, P. & Han, J. "A nanofilter array chip for fast gel-free biomolecule separation," Applied Physics Letters 87, 263902.1-3 (2005). (pdf†)
  2. Mao, P. & Han, J. "Fabrication and characterization of 20 nm nanofluidic channels by glass-glass and glass-silicon bonding," Lab on a Chip 5, 837-844 (2005). (pdf§)
  3. Wang, Y.-C., Stevens, A. & Han, J. "Million-fold preconcentration of proteins and peptides by nanofluidic filter," Analytical Chemistry 77, 4293-4299 (2005). (doi)

2004

  1. Han, J. & Singh, A. K. "Rapid protein separations in ultra-short microchannels: microchip sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing," Journal of Chromatrography A 1049, 205-209 (2004). (pdf, doi)
  2. Wang, Y.-C., Choi, M. H. & Han, J. "Two-dimensional protein separation with advanced sample and buffer isolation using microfluidic valves," Analytical Chemistry 76, 4426-4431 (2004). (doi)

Previous to 2002 (non-MIT)

  1. Han, J. & Craighead, H. G. "Characterization and optimization of an entropic trap for DNA separation," Analytical Chemistry 74, 394-401 (2002).
  2. Han, J. & Craighead, H. G. "Separation of long DNA molecules in a microfabricated entropic trap array," Science 288, 1026-1029 (2000).
  3. Chou, C.-F., Austin, R. H., Bakajin, O., Tegenfeldt, J. O., Castelino, J. A., Chan, S. S., Cox, E. C., Craighead, H. G., Darnton, N., Duke, T., Han, J. & Turner S. "Sorting biomolecules with microdevices," Electrophoresis 21, 81-90 (2000).
  4. Han, J., Turner, S. W. & Craighead, H. G. "Entropic trapping and escape of long DNA molecules at submicron size constriction," Physical Review Letters 83, 1688-1691 (1999).
  5. Han, J. & Craighead, H. G. "Entropic trapping and sieving of long DNA molecules in a nanofluidic channel," Journal of Vacuum Science Technology A 17, 2142-2147 (1999).
  6. Hill, S. B., Haich, C. A., Dunning, F. B., Walters, G. K., McClelland, J. J., Celotta, R. J., Craighead, H. G., Han, J. & Tanenbaum, D. M. "Patterning of octadecylsiloxane self-assembled monolayers on Si(100) using Ar(P-3(0,2)) atoms," Journal of Vacuum Science Technology B 17, 1087-1089 (1999).
  7. Han, J., Kuk, Y. & Jeon, D. "Surface crystalline gold silicide formation on the Au(100) surface," Surface Science 376, 237-244 (1997).

 

Proceedings of refereed conFerences

2008

  1. Moon D., Kim S.J., Kang I.S., Han J., "Protein preconcentration in a droplet-micro/nanochannel hybrid system," 61st Annual Meeting of the American Physical Society Division of Fluid Dynamics, San Antonio, USA, Nov. 2008.
  2. Kim S.J. and Han J., "Amplified Nonlinear Electrokinetics and Concentration Polarization near Nanofluidic Channel, MIT-Spain Workshop on Electrokinetics, Cambridge, USA, Oct. 2008.
  3. Han J., Wang Y.C., Kim S.J., "Engineering Applications of Ion Concentration Polarization," MIT-Spain Workshop on Electrokinetics, Cambridge, USA, Oct. 2008.
  4. Kim S.J., Li L.D., and Han J., " Amplified Electrokinetic Fluid Pumping and Switching by Concentration Polarization Near Nanofluidic Channel," mTAS 2008, San Diego, USA, Oct. 2008.
  5. Kim S.J. and Han J., "Self-Sealed Vertical Nanoporous Junctions for Integrating Various Nanomaterials in PDMS Microfluidic System," mTAS 2008, San Diego, USA, Oct. 2008.

2007

  1. Kim S.J., Wang Y.C., Lee J.H. and Han J., "Concentration Polarization and Nonlinear Electrokinetic Flow Inside/Outside the Ion Depletion Region," Gordon Research Conference on Physics & Chemistry of Microfluidics, Waterville Valley, NH, USA, Jul. 2007.

2006

  1. Fu, J. & Han, J. "Continuous-flow biomolecule separation through patterned anisotropic nanofluidic sieving structure," Proceedings of the MicroTAS 2006 Symposium, Tokyo, Japan, vol. 1, pp. 519-521. (oral presentation)
  2. Kim, S. J., Wang, Y.-C., Jang, H., Lee, J. H. & Han, J. "Nonlinear electrokinetic flow pattern near nanofluidic channel," Proceedings of the MicroTAS 2006 Symposium, Tokyo, Japan, vol. 1, pp. 522-524. (oral presentation)
  3. Kim, S. J., Song, Y. A., Skipper, P. L., Tannenbaum, S. R. & Han, J. "Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into accelerator mass spectrometry (AMS)," Proceedings of the MicroTAS 2006 Symposium, Tokyo, Japan, vol. 2, pp. 1076-1078. (poster presentation)

2005

  1. Mao, P. & Han, J. "Fabrication and characterization of planar nanofluidic channels and massively-parallel nanofluidic membranes," Proceedings of the MicroTAS 2005 Symposium, Boston, MA, vol. 1, pp. 678-680. (poster presentation)
  2. Wang, Y.-C., Tsau, C. H., Burg, T. P., Manalis, S. & Han, J. "Efficient biomolecule pre-concentration by nanofilter triggered electrokinetic trapping," Proceedings of the MicroTAS 2005 Symposium, Boston, MA, vol. 1, pp. 238-240. (poster presentation)
  3. Fu, J. & Han, J. "A nanofilter array chip for fast gel-free biomolecule separation," Proceedings of the MicroTAS 2005 Symposium, Boston, MA, vol. 2, pp. 1531-1533. (oral presentation)
  4. Song, Y.-A. & Han, J. "Continuous pI-based sorting of proteins and peptides in an microfluidic chip using diffusion potential," Proceedings of the MicroTAS 2005 Symposium, Boston, MA, vol. 2, pp. 1025-1027. (oral presentation)
  5. Wang, Y.-C., Fu, J., Mao, P. & Han, J. "Nanofluidic molecular filters for efficient protein separation and preconcentration", Proceedings of the Transducers 2005 conference, Seoul, Korea, vol. 1, pp. 352-355. (oral presentation)

2004

  1. Fu, J. & Han, J. "Biomolecule separation in nanofluidic filters by steric hindrance mechanism," Proceedings of the MicroTAS 2004 Symposium, Malmo, Sweden, vol. 1, pp. 285-287. (poster presentation)
  2. Han, J. & Fu J. "Biomolecule separation by steric hindrance using nanofluidic filters," 2004 IEEE-EMBS meeting, San Francisco, CA, pp. 2611-2614. (invited presentation)
  3. Choi, M. H., Wang, Y. -C. & Han, J. "On-chip isoelectric focusing coupled to micro liquid chromatography in blood proteomics," Proceedings of the MicroTAS 2004 Symposium, Malmo, Sweden, vol. 2, pp. 255-257. (poster presentation)

2003

  1. Wang, Y.-C., Choi, M. H. & Han, J. "On-chip IEF peak manipulation for 2D protein separation and MS coupling," Proceedings of the MicroTAS 2003 Symposium, Squaw Valley, CA, pp. 955-958. (poster presentation)

Previous to 2002 (non-MIT)

  1. Han, J. & Singh, A. K. "Miniaturization of protein separation: isoelectric focusing and SDS-PAGE," Proceedings of the MicroTAS 2002 Symposium, Nara, Japan, vol. 1, pp. 596-598. (poster presentation)
  2. Han, J. & Craighead, H. G. "From microfluidics to nanofluidics: DNA separation using nanofluidic entropic trap array device," Proceedings of SPIE 2000 - The International Society for Optical Engineering, 4177, pp. 42-48. (invited talk)


Other major publications

  1. Kim S.J. and Han J., "Nonlinear Electrokinetic FLow: Theory, Experiment, and Potential Applications,"
    IUTAM symposium on Advances in Micro- and Nanofluidics, Springer Science, 2009.
  2. Han, J. "Nanofluidics," a textbook chapter in "Introduction to Nanoscale Science and Technology," eds. Di Ventra, M., Evoy, S. & Heflin, J. R. (Kluwer Academic Publishers, Boston, 2004).

 

* These authors contributed equally to this work.

† Copyright by American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

‡ Copyright by the American Physical Society.

§ Do not make further available or distribute.

  
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