Integrated Biosystems and Biosensing

Develop advanced instrumentation for enhancing both basic research in cellular and molecular biology and the biological production of therapeutics and small molecules.

Facilities

Complete in-house microfluidic device fabrication capability.  Mode-locked lasers and spectrometers ranging from UV to IR with equipment for quantitative Raman analysis.

 

Team

Harry Lee, Kevin Lee

Publications

1. Lee, H.L.T., Boccazzi P., Ram R.J., and Sinskey, A.J. "Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control," Lab On a Chip, vol. 6, pp. 1229-1235, 2006. [PDF]
   
   
2. Lee, H.L.T, P. Boccazzi, N. Gorret, R.J. Ram, and A.J. Sinskey, "In situ bioprocess monitoring for Escherechia Coli using Raman spectroscopy," Vibrational Spectroscopy, vol. 35, issues 1-2, pp. 131-137, June 17, 2004. [PDF]
   
   
3. Lee, H.L.T and R.J. Ram,"Integrated fluid injectors and mixers for pH control in miniature bioreactor arrays," MicroTAS, 2005, Boston, MA. [PDF]
   
   
4. K. S. Lee, H. L. T. Lee, R. J. Ram, "Optical Multiplexing of Multiple Fluorescence Sensors For Compact Lab-On-A-Chip Systems," MicroTAS Conference 2007. [PDF]
    
5. Lee, K. S., Lee, H. L. T., Ram, R. J., "Polymer Waveguide Backplanes for Optical Sensor Interfaces in Microfluidics, "Lab on a Chip, vol. 7, pp. 1539-1545, 2007. [PDF]
   
   

6. K. S. Lee, R. J. Ram, “Plastic–PDMS bonding for high pressure hydrolytically stable active microfluidics,” Lab on a Chip, 2009, DOI: 10.1039/b820924c. [PDF]
   
   

7. K. S. Lee, R. J. Ram, “Optical Multiplexing of Multiple Fluorescence Sensors for Compact Lab-on-a-Chip Systems,” MicroTAS, Paris, October 2007. [PDF]
   
   

8. K. S. Lee, R. J. Ram, “Plastic-PDMS Hybrid Devices for High Pressure Hydrolytically Stable Active Microfluidics,” MicroTAS, San Diego, CA, October 2008. [PDF]
   

   
   

9. M. Fernandez, K. S. Lee, R. J. Ram, J. H. Correia, P. M. Mendez, “Flexible PDMS-based dry electrodes for electro-optic acquisition of ECG signals in wearable devices,” In Proceedings of the 32^nd Ann. Int. Conf. of the IEEE EMBS, Buenos Aires, Argentina, Aug 31-Sep 4, 2010. [PDF]

   
   
10. K. S. Lee, P. Boccazzi, A. J. Sinskey, R. J. Ram, “Microscale Controlled Continuous Cell Culture,” MicroTAS, Groningen, Netherlands, October 2010. [PDF]