Synthetic Biology Group, Professor Timothy Lu
  1. Tang, TC, Tham, E, Liu, X, Yehl, K, Rovner, AJ, Yuk, H, de la Fuente-Nunez, C, Isaacs, FJ, Zhao, X, Lu, TK. Hydrogel-based biocontainment of bacteria for continuous sensing and computation. Nat Chem Biol. 2021; :. doi: 10.1038/s41589-021-00779-6. PubMed PMID:33820990 .
  2. Cleto, S, Haslinger, K, Prather, KLJ, Lu, TK. Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica. BMC Biol. 2021;19 (1):46. doi: 10.1186/s12915-021-00971-z. PubMed PMID:33722216 PubMed Central PMC7962358.
  3. Torres, MDT, Cao, J, Franco, OL, Lu, TK, de la Fuente-Nunez, C. Synthetic Biology and Computer-Based Frameworks for Antimicrobial Peptide Discovery. ACS Nano. 2021;15 (2):2143-2164. doi: 10.1021/acsnano.0c09509. PubMed PMID:33538585 .
  4. Pires, DP, Monteiro, R, Mil-Homens, D, Fialho, A, Lu, TK, Azeredo, J. Designing P. aeruginosa synthetic phages with reduced genomes. Sci Rep. 2021;11 (1):2164. doi: 10.1038/s41598-021-81580-2. PubMed PMID:33495501 PubMed Central PMC7835345.
  5. Torres, MDT, Voskian, S, Brown, P, Liu, A, Lu, TK, Hatton, TA, de la Fuente-Nunez, C. Coatable and Resistance-Proof Ionic Liquid for Pathogen Eradication. ACS Nano. 2021;15 (1):966-978. doi: 10.1021/acsnano.0c07642. PubMed PMID:33438392 .
  6. Gilbert, C, Tang, TC, Ott, W, Dorr, BA, Shaw, WM, Sun, GL, Lu, TK, Ellis, T. Living materials with programmable functionalities grown from engineered microbial co-cultures. Nat Mater. 2021; :. doi: 10.1038/s41563-020-00857-5. PubMed PMID:33432140 .
  7. Lenneman, BR, Fernbach, J, Loessner, MJ, Lu, TK, Kilcher, S. Enhancing phage therapy through synthetic biology and genome engineering. Curr Opin Biotechnol. 2020;68 :151-159. doi: 10.1016/j.copbio.2020.11.003. PubMed PMID:33310655 .
  8. Silva, ON, Torres, MDT, Cao, J, Alves, ESF, Rodrigues, LV, Resende, JM, Lião, LM, Porto, WF, Fensterseifer, ICM, Lu, TK, Franco, OL, de la Fuente-Nunez, C. Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties. Proc Natl Acad Sci U S A. 2020;117 (43):26936-26945. doi: 10.1073/pnas.2012379117. PubMed PMID:33046640 PubMed Central PMC7604428.
  9. Valeri, JA, Collins, KM, Ramesh, P, Alcantar, MA, Lepe, BA, Lu, TK, Camacho, DM. Sequence-to-function deep learning frameworks for engineered riboregulators. Nat Commun. 2020;11 (1):5058. doi: 10.1038/s41467-020-18676-2. PubMed PMID:33028819 PubMed Central PMC7541510.
  10. Lai, Y, Babunovic, GH, Cui, L, Dedon, PC, Doench, JG, Fortune, SM, Lu, TK. Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens. Cell Syst. 2020;11 (3):239-251.e7. doi: 10.1016/j.cels.2020.08.010. PubMed PMID:32970993 .
  11. Inda, ME, Lu, TK. Microbes as Biosensors. Annu Rev Microbiol. 2020;74 :337-359. doi: 10.1146/annurev-micro-022620-081059. PubMed PMID:32660390 .
  12. Chen, CH, Lu, TK. Development and Challenges of Antimicrobial Peptides for Therapeutic Applications. Antibiotics (Basel). 2020;9 (1):. doi: 10.3390/antibiotics9010024. PubMed PMID:31941022 PubMed Central PMC7168295.
  13. Higashikuni, Y, Lu, TK. Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells. ACS Synth Biol. 2019;8 (12):2607-2619. doi: 10.1021/acssynbio.9b00297. PubMed PMID:31751114 .
  14. Inda, ME, Broset, E, Lu, TK, de la Fuente-Nunez, C. Emerging Frontiers in Microbiome Engineering. Trends Immunol. 2019;40 (10):952-973. doi: 10.1016/j.it.2019.08.007. PubMed PMID:31601521 .
  15. Yehl, K, Lemire, S, Yang, AC, Ando, H, Mimee, M, Torres, MT, de la Fuente-Nunez, C, Lu, TK. Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis. Cell. 2019;179 (2):459-469.e9. doi: 10.1016/j.cell.2019.09.015. PubMed PMID:31585083 PubMed Central PMC6924272.
  16. Wang, J, Alvin Chew, BL, Lai, Y, Dong, H, Xu, L, Balamkundu, S, Cai, WM, Cui, L, Liu, CF, Fu, XY, Lin, Z, Shi, PY, Lu, TK, Luo, D, Jaffrey, SR, Dedon, PC. Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic Acids Res. 2019;47 (20):e130. doi: 10.1093/nar/gkz751. PubMed PMID:31504804 PubMed Central PMC6847653.
  17. Müller, IE, Rubens, JR, Jun, T, Graham, D, Xavier, R, Lu, TK. Gene networks that compensate for crosstalk with crosstalk. Nat Commun. 2019;10 (1):4028. doi: 10.1038/s41467-019-12021-y. PubMed PMID:31492904 PubMed Central PMC6731275.
  18. Farzadfard, F, Gharaei, N, Higashikuni, Y, Jung, G, Cao, J, Lu, TK. Single-Nucleotide-Resolution Computing and Memory in Living Cells. Mol Cell. 2019;75 (4):769-780.e4. doi: 10.1016/j.molcel.2019.07.011. PubMed PMID:31442423 PubMed Central PMC7001763.
  19. Olmez, TT, Sahin Kehribar, E, Isilak, ME, Lu, TK, Seker, UOS. Synthetic Genetic Circuits for Self-Actuated Cellular Nanomaterial Fabrication Devices. ACS Synth Biol. 2019;8 (9):2152-2162. doi: 10.1021/acssynbio.9b00235. PubMed PMID:31419103 .
  20. Oshiro, KGN, Cândido, ES, Chan, LY, Torres, MDT, Monges, BED, Rodrigues, SG, Porto, WF, Ribeiro, SM, Henriques, ST, Lu, TK, de la Fuente-Nunez, C, Craik, DJ, Franco, OL, Cardoso, MH. Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties. J Med Chem. 2019;62 (17):8140-8151. doi: 10.1021/acs.jmedchem.9b00915. PubMed PMID:31411881 .
  21. Lu, Timothy K